Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain
نویسندگان
چکیده
منابع مشابه
Isobolographic antinociception of non-steroidal anti-inflammatory drugs in rodent formalin orofacial pain
Diverse studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception through inhibition of cyclooxygenases. In this study was evaluated the effect of NSAIDs to induce antinociception either alone or in combination in the formalin orofacial test of rodent. Male mice were injected intraperitoneally with dexibuprofen, dexktoprofen, diclofenac meloxicam, metamizol, and...
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Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
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The modern science of drug testing began to mature in the 1960s, when scientific methodology developed the capability to provide demonstrable safety and efficacy data on new drugs, such as those used for the pharmacotherapy of pain. In subsequent decades, standardized models have been developed that constitute a key component of a sophisticated methodology permitting the objective investigation...
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Combination therapies have long been used to treat inflammation while reducing side effects. The present study was designed to evaluate the therapeutic potential of combination treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and previously undescribed soluble epoxide hydrolase inhibitors (sEHIs) in lipopolysaccharide (LPS)-challenged mice. NSAIDs inhibit cyclooxygenase (COX) enzyme...
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It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.
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ژورنال
عنوان ژورنال: Pharmaceutical and Biomedical Research
سال: 2020
ISSN: 2423-4494,2423-4486
DOI: 10.18502/pbr.v6i3.4647